脑外伤康复结果与基因有关

    周卫东大夫论文引起欧美专家关注。周为论文通信作者。该论文分析研究表明: ApoE4基因型与脑外伤最初严重程度无关, 但ApoE4基因型患者脑外伤6个月后康复结果不良相关(论文文摘见最下).

    该论文是周卫东大夫带领他的硕士研究生完成一项APOE4基因型与脑外伤预后的研究，该长达13页的论文于2008年4月在著名国际杂志J of Neurotrauma上发表了其研究成果，该研究成果引起了欧美专家的关注。
    举例如下：美国纽约Burke康复医院的Jordan教授征求周博士的意见是否能在葡萄牙的国际脑损伤会议上论及周的研究成果。西班牙Hospital NISA Valencia al Ma 医院的脑损伤专家Enrique Noé向周卫东博士表达对周博士研究成果的兴趣并向周博士索要论文。美国佛罗里达Roskamp Institute 的Chao Jin博士向周博士表达对论文的兴趣，并索要论文全文。
（参见邮件）

1，美国纽约Burke康复医院的Jordan教授征求周博士的意见是否能在葡萄牙的国际脑损伤会议上论及周的研究成果。
Weidong Zhou> Date: Thu, 13 Mar 2008 08:00:55 -0400> From:
bjordan@burke.org> To: weidongzhou732@hotmail.com> Subject: RE: PDF
paper> >
That is great! I am giving talk at the International Brain
Injury Association meeting in Lisbon, Portugal in April. Is it OK if I
mention your study
Barry Jordan
Burke Rehabilitation Hospital，NY

2，西班牙Hospital NISA Valencia al Ma 医院的脑损伤专家向周卫东博士表达对周博士研究成果的兴趣并向周博士索要论文。
"enoe@comv.es" <enoe@comv.es>
ViewTuesday, September 23, 2008 7:05:48 PM
To:weidongzh@yahoo.com
Dear Dr. Weidong:
I have read with great interest the abstract of your last paper published
in Journal of Neurotrauma (Meta-analysis of APOE4 allele and outcome after
traumatic brain injury). It would be of great value for our research group
if you could kindly send us a copy of your manuscript.

Thanks in advance four your help.
Sincerely

Enrique Noé MD. PhD
Brain Injury Service
Hospital NISA Valencia al Mar
Spain
www.serviciodc.com

3，美国佛罗里达Roskamp Institute 的Chao Jin博士向周博士表达对论文的兴趣，并索要论文全文。
________________________________________
From: "CJin@rfdn.org" <CJin@rfdn.org>
To: weidongzh@yahoo.com
Sent: Tuesday, December 9, 2008 5:04:09 AM
Subject: Paper help
Dear Dr. Weidong,
I am very interested in your published paper titled "Meta-analysis of APOE4 allele and outcome after traumatic brain injury" J. Neurotrauma. 2008 Apr; 25(4):279-90. If possible, could you please send me a copy of it in pdf.
Thanks in advance.
Chao Jin

文摘如下

J Neurotrauma. 2008 Apr;25(4):279-90

Meta-analysis of APOE4 allele and outcome after traumatic brain injury.
Zhou W, Xu D, Peng X, Zhang Q, Jia J, Crutcher KA.

There is conflicting evidence regarding a possible association between the apolipoprotein E4 (APOE4) allele and the consequences of traumatic brain injury (TBI). Our aim was to carry out a meta-analysis of cohort studies of sufficient rigor to determine whether the presence of the APOE4 allele contributes to initial injury severity and/or poor outcome following TBI. MEDLINE, EMBase, CBMdisc, and CNKI databases were searched for literature published from January 1993 to October 2007. Of the 100 identified studies, 14 cohort studies were selected for analysis based on comprehensive quality assessment using a standardized scale. Data from the 14 eligible cohort studies included a total of 2527 participants, 736 with and 1791 without the APOE4 allele. The APOE4 allele was not associated with initial injury severity of TBI. The pooled RR were 1.11 (95% confidence interval [CI], 0.91 to 1.35) for severe injury, 1.06 (95% CI, 0.86-1.31) for moderate injury and 0.93 (95% CI, 0.81-1.06) for mild injury. However, the APOE4 allele was significantly associated with a poor outcome of TBI at 6 months after injury (RR = 1.36; 95% CI, 1.04-1.78). The association remained significant in sensitivity tests. This meta-analysis indicates that the presence of the APOE4 allele is not associated with the initial severity of brain injury following TBI but is associated with increased risk of poor long-term outcome at 6 months after injury.

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